diff --git a/CHANGELOG.md b/CHANGELOG.md
index c47f8e7ae..a51566808 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,11 @@
 # Changelog
 
+## [unreleased]
+
+### Changed
+
+- Multi-grid label dropdown will only show label names from visible alerts.
+
 ## v0.80
 
 ### Added
diff --git a/ui/src/Components/Grid/AlertGrid/GridLabelSelect.test.tsx b/ui/src/Components/Grid/AlertGrid/GridLabelSelect.test.tsx
index 301c3a54b..466c5222f 100644
--- a/ui/src/Components/Grid/AlertGrid/GridLabelSelect.test.tsx
+++ b/ui/src/Components/Grid/AlertGrid/GridLabelSelect.test.tsx
@@ -5,9 +5,12 @@ import { mount } from "enzyme";
 
 import fetchMock from "fetch-mock";
 
+import { MockGrid } from "__fixtures__/Stories";
+import { AlertStore } from "Stores/AlertStore";
 import { Settings } from "Stores/Settings";
 import { GridLabelSelect } from "./GridLabelSelect";
 
+let alertStore: AlertStore;
 let settingsStore: Settings;
 
 beforeEach(() => {
@@ -16,13 +19,16 @@ beforeEach(() => {
     body: JSON.stringify([]),
   });
 
+  alertStore = new AlertStore([]);
   settingsStore = new Settings(null);
 
   jest.useFakeTimers();
 });
 
 const MountedGridLabelSelect = () => {
-  return mount(<GridLabelSelect settingsStore={settingsStore} />);
+  return mount(
+    <GridLabelSelect alertStore={alertStore} settingsStore={settingsStore} />
+  );
 };
 
 describe("<GridLabelSelect />", () => {
@@ -35,6 +41,7 @@ describe("<GridLabelSelect />", () => {
 
   it("clicking toggle renders select dropdown", async () => {
     const promise = Promise.resolve();
+    MockGrid(alertStore);
     const tree = MountedGridLabelSelect();
     const toggle = tree.find("span.components-grid-label-select-dropdown");
     toggle.simulate("click");
@@ -42,6 +49,22 @@ describe("<GridLabelSelect />", () => {
     await act(() => promise);
   });
 
+  it("clicking an option updates grid settings", async () => {
+    const promise = Promise.resolve();
+    MockGrid(alertStore);
+    const tree = MountedGridLabelSelect();
+
+    const toggle = tree.find("span.components-grid-label-select-dropdown");
+    toggle.simulate("click");
+    expect(tree.find("div.components-grid-label-select-menu")).toHaveLength(1);
+
+    settingsStore.multiGridConfig.config.gridLabel = "foo";
+    const options = tree.find("div.react-select__option");
+    options.at(4).simulate("click");
+    expect(settingsStore.multiGridConfig.config.gridLabel).toBe("cluster");
+    await act(() => promise);
+  });
+
   it("clicking toggle twice hides select dropdown", async () => {
     const promise = Promise.resolve();
     const tree = MountedGridLabelSelect();
diff --git a/ui/src/Components/Grid/AlertGrid/GridLabelSelect.tsx b/ui/src/Components/Grid/AlertGrid/GridLabelSelect.tsx
index 6be20491e..0e5425e2e 100644
--- a/ui/src/Components/Grid/AlertGrid/GridLabelSelect.tsx
+++ b/ui/src/Components/Grid/AlertGrid/GridLabelSelect.tsx
@@ -11,23 +11,96 @@ import { observer } from "mobx-react-lite";
 
 import { Manager, Reference, Popper } from "react-popper";
 
+import AsyncSelect from "react-select/async";
+
 import { FontAwesomeIcon } from "@fortawesome/react-fontawesome";
 import { faCaretDown } from "@fortawesome/free-solid-svg-icons/faCaretDown";
 
+import { AlertStore } from "Stores/AlertStore";
 import { Settings } from "Stores/Settings";
 import { CommonPopperModifiers } from "Common/Popper";
+import { NewLabelName, StringToOption, OptionT } from "Common/Select";
 import { DropdownSlide } from "Components/Animations/DropdownSlide";
+import { ThemeContext } from "Components/Theme";
 import { useOnClickOutside } from "Hooks/useOnClickOutside";
-import { GridLabelName } from "Components/MainModal/Configuration/GridLabelName";
 
 const NullContainer: FC = () => null;
 
+const GridLabelNameSelect: FC<{
+  alertStore: AlertStore;
+  settingsStore: Settings;
+}> = ({ alertStore, settingsStore }) => {
+  const loadOptions = (
+    inputValue: string,
+    callback: (options: OptionT[]) => void
+  ) => {
+    const labelNames: { [key: string]: boolean } = {
+      "@alertmanager": true,
+      "@cluster": true,
+      "@receiver": true,
+    };
+
+    alertStore.data.grids.forEach((grid) => {
+      labelNames[grid.labelName] = true;
+      grid.alertGroups.forEach((group) => {
+        Object.keys(group.labels).forEach((name) => {
+          labelNames[name] = true;
+        });
+        Object.keys(group.shared.labels).forEach((name) => {
+          labelNames[name] = true;
+        });
+        group.alerts.forEach((alert) => {
+          Object.keys(alert.labels).forEach((name) => {
+            labelNames[name] = true;
+          });
+        });
+      });
+    });
+
+    callback(
+      Object.keys(labelNames)
+        .sort()
+        .map((key) => StringToOption(key))
+    );
+  };
+
+  const context = React.useContext(ThemeContext);
+
+  return (
+    <AsyncSelect
+      styles={context.reactSelectStyles}
+      classNamePrefix="react-select"
+      formatCreateLabel={NewLabelName}
+      loadOptions={loadOptions}
+      defaultOptions
+      onChange={(option) => {
+        settingsStore.multiGridConfig.config.gridLabel = (option as OptionT).value;
+      }}
+      menuIsOpen={true}
+      components={{
+        ClearIndicator: null,
+        IndicatorSeparator: null,
+        DropdownIndicator: null,
+        ValueContainer: NullContainer,
+        Control: NullContainer,
+      }}
+    />
+  );
+};
+
 const Dropdown: FC<{
   popperPlacement?: string;
   popperRef?: Ref<HTMLDivElement>;
   popperStyle?: CSSProperties;
+  alertStore: AlertStore;
   settingsStore: Settings;
-}> = ({ popperPlacement, popperRef, popperStyle, settingsStore }) => {
+}> = ({
+  popperPlacement,
+  popperRef,
+  popperStyle,
+  alertStore,
+  settingsStore,
+}) => {
   return (
     <div
       className="dropdown-menu d-block shadow components-grid-label-select-menu border-0 p-0"
@@ -39,24 +112,18 @@ const Dropdown: FC<{
       }}
       data-placement={popperPlacement}
     >
-      <GridLabelName
+      <GridLabelNameSelect
+        alertStore={alertStore}
         settingsStore={settingsStore}
-        isOpen={true}
-        selectComponents={{
-          ClearIndicator: null,
-          IndicatorSeparator: null,
-          DropdownIndicator: null,
-          ValueContainer: NullContainer,
-          Control: NullContainer,
-        }}
       />
     </div>
   );
 };
 
 const GridLabelSelect: FC<{
+  alertStore: AlertStore;
   settingsStore: Settings;
-}> = observer(({ settingsStore }) => {
+}> = observer(({ alertStore, settingsStore }) => {
   const [isVisible, setIsVisible] = useState<boolean>(false);
   const hide = useCallback(() => setIsVisible(false), []);
   const toggle = useCallback(() => setIsVisible(!isVisible), [isVisible]);
@@ -86,6 +153,7 @@ const GridLabelSelect: FC<{
                 popperPlacement={placement}
                 popperRef={ref}
                 popperStyle={style}
+                alertStore={alertStore}
                 settingsStore={settingsStore}
               />
             )}
diff --git a/ui/src/Components/Grid/AlertGrid/Swimlane.tsx b/ui/src/Components/Grid/AlertGrid/Swimlane.tsx
index 22a0d686b..63d0e0cee 100644
--- a/ui/src/Components/Grid/AlertGrid/Swimlane.tsx
+++ b/ui/src/Components/Grid/AlertGrid/Swimlane.tsx
@@ -41,7 +41,10 @@ const Swimlane: FC<{
           className="flex-shrink-0 flex-grow-1 px-0"
           style={{ minWidth: "0px" }}
         >
-          <GridLabelSelect settingsStore={settingsStore} />
+          <GridLabelSelect
+            alertStore={alertStore}
+            settingsStore={settingsStore}
+          />
         </span>
       )}
       <span className="flex-shrink-0 flex-grow-0 ml-2 mr-0">
diff --git a/ui/src/Components/MainModal/Configuration/GridLabelName.tsx b/ui/src/Components/MainModal/Configuration/GridLabelName.tsx
index 9939b09dc..13068d55d 100644
--- a/ui/src/Components/MainModal/Configuration/GridLabelName.tsx
+++ b/ui/src/Components/MainModal/Configuration/GridLabelName.tsx
@@ -1,7 +1,6 @@
 import React, { FC } from "react";
 
 import Creatable from "react-select/creatable";
-import { GroupTypeBase, SelectComponentsConfig } from "react-select";
 
 import { useFetchGet } from "Hooks/useFetchGet";
 import { FormatBackendURI } from "Stores/AlertStore";
@@ -25,11 +24,7 @@ const staticValues = [
 
 const GridLabelName: FC<{
   settingsStore: Settings;
-  isOpen?: boolean | undefined;
-  selectComponents?:
-    | Partial<SelectComponentsConfig<OptionT, false, GroupTypeBase<OptionT>>>
-    | undefined;
-}> = ({ settingsStore, isOpen = undefined, selectComponents = undefined }) => {
+}> = ({ settingsStore }) => {
   const { response } = useFetchGet<string[]>(
     FormatBackendURI(`labelNames.json`)
   );
@@ -56,8 +51,6 @@ const GridLabelName: FC<{
       onChange={(option) => {
         settingsStore.multiGridConfig.config.gridLabel = (option as OptionT).value;
       }}
-      menuIsOpen={isOpen}
-      components={selectComponents}
     />
   );
 };