diff --git a/ui/package.json b/ui/package.json
index 90ed8f0b3..d8afad5e4 100644
--- a/ui/package.json
+++ b/ui/package.json
@@ -50,6 +50,7 @@
     "react-tippy": "1.2.3",
     "react-transition-group": "4.0.0",
     "react-truncate": "2.4.0",
+    "semver": "6.0.0",
     "whatwg-fetch": "3.0.0"
   },
   "scripts": {
diff --git a/ui/src/Components/Grid/AlertGrid/AlertGroup/Silence/DeleteSilence.js b/ui/src/Components/Grid/AlertGrid/AlertGroup/Silence/DeleteSilence.js
index 586933a09..256297fac 100644
--- a/ui/src/Components/Grid/AlertGrid/AlertGroup/Silence/DeleteSilence.js
+++ b/ui/src/Components/Grid/AlertGrid/AlertGroup/Silence/DeleteSilence.js
@@ -4,6 +4,8 @@ import PropTypes from "prop-types";
 import { observable, action } from "mobx";
 import { observer } from "mobx-react";
 
+import semver from "semver";
+
 import { FontAwesomeIcon } from "@fortawesome/react-fontawesome";
 import { faTrash } from "@fortawesome/free-solid-svg-icons/faTrash";
 import { faExclamationCircle } from "@fortawesome/free-solid-svg-icons/faExclamationCircle";
@@ -119,9 +121,7 @@ const DeleteSilenceModalContent = observer(
         ]);
 
       this.previewState.fetch = fetch(alertsURI, { credentials: "include" })
-        .then(result => {
-          return result.json();
-        })
+        .then(result => result.json())
         .then(result => {
           this.previewState.groupsToUniqueLabels(Object.values(result.groups));
           this.previewState.setError(null);
@@ -140,13 +140,29 @@ const DeleteSilenceModalContent = observer(
       // if it's already deleted then do nothing
       if (this.deleteState.done && this.deleteState.error === null) return;
 
-      const uri = `${alertmanager.publicURI}/api/v1/silence/${silenceID}`;
+      const isOpenAPI = semver.satisfies(alertmanager.version, ">=0.16.0");
+
+      const uri = isOpenAPI
+        ? `${alertmanager.publicURI}/api/v2/silence/${silenceID}`
+        : `${alertmanager.publicURI}/api/v1/silence/${silenceID}`;
+
       this.deleteState.fetch = fetch(uri, {
         method: "DELETE",
         credentials: "include"
       })
-        .then(result => result.json())
-        .then(result => this.parseAlertmanagerResponse(result))
+        .then(result => {
+          if (isOpenAPI) {
+            if (result.ok) {
+              this.deleteState.setError(null);
+              this.deleteState.setDone();
+            } else {
+              result.text().then(this.deleteState.setError);
+              this.deleteState.setDone();
+            }
+          } else {
+            result.json().then(this.parseAlertmanagerResponse);
+          }
+        })
         .catch(err => {
           console.trace(err);
           this.deleteState.setDone();
diff --git a/ui/src/Components/Grid/AlertGrid/AlertGroup/Silence/DeleteSilence.test.js b/ui/src/Components/Grid/AlertGrid/AlertGroup/Silence/DeleteSilence.test.js
index 9da08c88d..a119c9309 100644
--- a/ui/src/Components/Grid/AlertGrid/AlertGroup/Silence/DeleteSilence.test.js
+++ b/ui/src/Components/Grid/AlertGrid/AlertGroup/Silence/DeleteSilence.test.js
@@ -13,6 +13,7 @@ let alertStore;
 beforeEach(() => {
   alertmanager = MockAlertmanager();
   alertStore = new AlertStore([]);
+  alertStore.data.upstreams.instances[0] = alertmanager;
   fetch.mockResponseOnce(JSON.stringify(MockAPIResponse()));
 
   jest.restoreAllMocks();
@@ -121,7 +122,7 @@ describe("<DeleteSilenceModalContent />", () => {
     expect(tree.find("ErrorMessage")).toHaveLength(1);
   });
 
-  it("sends a DELETE request after clicking 'Confirm' button", async () => {
+  it("[v1] sends a DELETE request after clicking 'Confirm' button ", async () => {
     await VerifyResponse({ status: "success" });
     expect(fetch.mock.calls[1][0]).toBe(
       "http://am.example.com/api/v1/silence/123456789"
@@ -129,6 +130,15 @@ describe("<DeleteSilenceModalContent />", () => {
     expect(fetch.mock.calls[1][1]).toMatchObject({ method: "DELETE" });
   });
 
+  it("[v2] sends a DELETE request after clicking 'Confirm' button ", async () => {
+    alertmanager.version = "0.16.2";
+    await VerifyResponse({ status: "success" });
+    expect(fetch.mock.calls[1][0]).toBe(
+      "http://am.example.com/api/v2/silence/123456789"
+    );
+    expect(fetch.mock.calls[1][1]).toMatchObject({ method: "DELETE" });
+  });
+
   it("'Confirm' button is no-op after successful DELETE", async () => {
     const tree = await VerifyResponse({ status: "success" });
     expect(fetch.mock.calls[1][0]).toBe(
@@ -165,7 +175,7 @@ describe("<DeleteSilenceModalContent />", () => {
     expect(tree.find("ErrorMessage")).toHaveLength(1);
   });
 
-  it("renders ErrorMessage on failed fetch request", async () => {
+  it("[v1] renders ErrorMessage on failed fetch request", async () => {
     const tree = MountedDeleteSilenceModalContent();
     await expect(tree.instance().previewState.fetch).resolves.toBeUndefined();
 
@@ -179,4 +189,20 @@ describe("<DeleteSilenceModalContent />", () => {
     tree.update();
     expect(tree.find("ErrorMessage")).toHaveLength(1);
   });
+
+  it("[v2] renders ErrorMessage on failed fetch request", async () => {
+    alertmanager.version = "0.16.2";
+    const tree = MountedDeleteSilenceModalContent();
+    await expect(tree.instance().previewState.fetch).resolves.toBeUndefined();
+
+    jest.spyOn(console, "trace").mockImplementation(() => {});
+    fetch.resetMocks();
+    fetch.mockResponseOnce("500 Internal Server Error", { status: 500 });
+
+    tree.find(".btn-outline-danger").simulate("click");
+    await expect(tree.instance().deleteState.fetch).resolves.toBeUndefined();
+
+    tree.update();
+    expect(tree.find("ErrorMessage")).toHaveLength(1);
+  });
 });
diff --git a/ui/src/Components/SilenceModal/SilenceSubmit/SilenceSubmitProgress.js b/ui/src/Components/SilenceModal/SilenceSubmit/SilenceSubmitProgress.js
index bbfec10d4..45c322ae7 100644
--- a/ui/src/Components/SilenceModal/SilenceSubmit/SilenceSubmitProgress.js
+++ b/ui/src/Components/SilenceModal/SilenceSubmit/SilenceSubmitProgress.js
@@ -4,6 +4,8 @@ import PropTypes from "prop-types";
 import { action, observable } from "mobx";
 import { observer } from "mobx-react";
 
+import semver from "semver";
+
 import { FontAwesomeIcon } from "@fortawesome/react-fontawesome";
 import { faCircleNotch } from "@fortawesome/free-solid-svg-icons/faCircleNotch";
 import { faCheckCircle } from "@fortawesome/free-regular-svg-icons/faCheckCircle";
@@ -54,7 +56,8 @@ const SilenceSubmitProgress = observer(
         startsAt: PropTypes.string.isRequired,
         endsAt: PropTypes.string.isRequired,
         createdBy: PropTypes.string.isRequired,
-        comment: PropTypes.string.isRequired
+        comment: PropTypes.string.isRequired,
+        id: PropTypes.string
       }).isRequired,
       alertStore: PropTypes.instanceOf(AlertStore).isRequired
     };
@@ -99,7 +102,13 @@ const SilenceSubmitProgress = observer(
         return;
       }
 
-      this.submitState.fetch = fetch(`${am.publicURI}/api/v1/silences`, {
+      const isOpenAPI = semver.satisfies(am.version, ">=0.16.0");
+
+      const uri = isOpenAPI
+        ? `${am.publicURI}/api/v2/silences`
+        : `${am.publicURI}/api/v1/silences`;
+
+      this.submitState.fetch = fetch(uri, {
         method: "POST",
         body: JSON.stringify(payload),
         headers: {
@@ -107,9 +116,34 @@ const SilenceSubmitProgress = observer(
         },
         credentials: "include"
       })
-        .then(result => result.json())
-        .then(result => this.parseAlertmanagerResponse(am.uri, result))
-        .catch(err => this.maybeTryAgainAfterError(err));
+        .then(result => {
+          if (isOpenAPI) {
+            if (result.ok) {
+              return result
+                .json()
+                .then(r => this.parseOpenAPIResponse(am.uri, r));
+            } else {
+              return result.text().then(text => {
+                this.submitState.markFailed(text);
+                return text;
+              });
+            }
+          } else {
+            return result
+              .json()
+              .then(r => this.parseAlertmanagerResponse(am.uri, r));
+          }
+        })
+        .catch(err => {
+          this.maybeTryAgainAfterError(err);
+        });
+    };
+
+    parseOpenAPIResponse = (uri, response) => {
+      const link = <SilenceLink uri={uri} silenceId={response.silenceID} />;
+      this.submitState.markDone(link);
+      // return silenceId so we can assert it in tests
+      return response.silenceID;
     };
 
     parseAlertmanagerResponse = (uri, response) => {
diff --git a/ui/src/Components/SilenceModal/SilenceSubmit/SilenceSubmitProgress.test.js b/ui/src/Components/SilenceModal/SilenceSubmit/SilenceSubmitProgress.test.js
index 6e18f0de2..446cd2d2d 100644
--- a/ui/src/Components/SilenceModal/SilenceSubmit/SilenceSubmitProgress.test.js
+++ b/ui/src/Components/SilenceModal/SilenceSubmit/SilenceSubmitProgress.test.js
@@ -48,7 +48,15 @@ describe("<SilenceSubmitProgress />", () => {
     expect(fetch.mock.calls).toHaveLength(1);
   });
 
-  it("appends /api/v1/silences to the passed URI", async () => {
+  it("[v1] appends /api/v1/silences to the passed URI", async () => {
+    const tree = MountedSilenceSubmitProgress();
+    await expect(tree.instance().submitState.fetch).resolves.toBeUndefined();
+    const uri = fetch.mock.calls[0][0];
+    expect(uri).toBe("http://example.com/api/v1/silences");
+  });
+
+  it("[v2] appends /api/v2/silences to the passed URI", async () => {
+    alertStore.data.upstreams.instances[0].version = "0.16.2";
     const tree = MountedSilenceSubmitProgress();
     await expect(tree.instance().submitState.fetch).resolves.toBeUndefined();
     const uri = fetch.mock.calls[0][0];
@@ -188,7 +196,7 @@ describe("<SilenceSubmitProgress />", () => {
     expect(tree.text()).toBe("mockAlertmanagermock error message");
   });
 
-  it("renders success icon on successful fetch", async () => {
+  it("[v1] renders success icon on successful fetch", async () => {
     fetch.mockResponseOnce(
       JSON.stringify({ status: "success", data: { silenceId: "123" } })
     );
@@ -199,7 +207,36 @@ describe("<SilenceSubmitProgress />", () => {
     expect(tree.find("FontAwesomeIcon.text-danger")).toHaveLength(0);
   });
 
-  it("renders error icon on failed fetch", async () => {
+  it("[v1] renders silence link on successful fetch", async () => {
+    fetch.mockResponseOnce(
+      JSON.stringify({ status: "success", data: { silenceId: "123" } })
+    );
+    const tree = MountedSilenceSubmitProgress();
+    await expect(tree.instance().submitState.fetch).resolves.toBe("success");
+    tree.update();
+    expect(tree.find("a").getDOMNode().getAttribute("href")).toBe("file:///mock/#/silences/123");
+  });
+
+  it("[v2] renders success icon on successful fetch", async () => {
+    alertStore.data.upstreams.instances[0].version = "0.16.2";
+    fetch.mockResponseOnce(JSON.stringify({ silenceID: "123" }));
+    const tree = MountedSilenceSubmitProgress();
+    await expect(tree.instance().submitState.fetch).resolves.toBe("123");
+    tree.update();
+    expect(tree.find("FontAwesomeIcon.text-success")).toHaveLength(1);
+    expect(tree.find("FontAwesomeIcon.text-danger")).toHaveLength(0);
+  });
+
+  it("[v2] renders silence link on successful fetch", async () => {
+    alertStore.data.upstreams.instances[0].version = "0.16.2";
+    fetch.mockResponseOnce(JSON.stringify({ silenceID: "123" }));
+    const tree = MountedSilenceSubmitProgress();
+    await expect(tree.instance().submitState.fetch).resolves.toBe("123");
+    tree.update();
+    expect(tree.find("a").getDOMNode().getAttribute("href")).toBe("file:///mock/#/silences/123");
+  });
+
+  it("[v1] renders error icon on failed fetch", async () => {
     fetch.mockResponseOnce(JSON.stringify({ status: "error" }));
     const tree = MountedSilenceSubmitProgress();
     await expect(tree.instance().submitState.fetch).resolves.toBe("error");
@@ -208,6 +245,18 @@ describe("<SilenceSubmitProgress />", () => {
     expect(tree.find("FontAwesomeIcon.text-danger")).toHaveLength(1);
   });
 
+  it("[v2] renders error icon on failed fetch", async () => {
+    alertStore.data.upstreams.instances[0].version = "0.16.2";
+    fetch.mockResponseOnce("error message", { status: 500 });
+    const tree = MountedSilenceSubmitProgress();
+    await expect(tree.instance().submitState.fetch).resolves.toBe(
+      "error message"
+    );
+    tree.update();
+    expect(tree.find("FontAwesomeIcon.text-success")).toHaveLength(0);
+    expect(tree.find("FontAwesomeIcon.text-danger")).toHaveLength(1);
+  });
+
   it("renders unhandled 'status' values in the response as error", async () => {
     fetch.mockResponseOnce(JSON.stringify({ status: "unhandled" }));
     const tree = MountedSilenceSubmitProgress();